"Choose your battles wisely."
It's an adage we've all heard at some point in our lives and one that holds truth. It's trivial to pursue a discussion or argument about every little thing that goes wrong or irritates you. If you do choose to nitpick, you run the risk of burying your significant other in criticism that will only weaken your relationship. Relationships are hard enough on their own without the added ridiculousness of regular bickering.
Personally, I hate when someone tries to pick a fight with me for no good reason about something that isn't even remotely important. If you're just trying to broach a pet-peeve, then talk about what's bothering you rather than just pushing the other person's buttons and causing an unnecessary argument. If you're upset about something that's happened, be forthright and talk about it. Taking the passive aggressive route and making a big deal about small things without addressing the real issue at hand isn't going to do you any favors.
When it seems like a person is trying to start a dispute over something that is seemingly meaningless, I just choose to bite my tongue and let it roll off my back. Why indulge the other person in a quibble that is going to leave me having less than ideal feelings for them? So I don't touch it with a ten-foot pole. I let it go. I choose not to engage in those battles even though someone else chose to attempt one.
Long story short - choose your battles and choose them wisely or you could end sabotaging your relationship. Unless of course you have a significant other who is constantly giving you their endless forgiveness over such trite things. Just make sure there's a bottomless pit of it first.